Telik's Proteasome Inhibitor Program Meets A Preclinical Development Milestone

�Telik, Inc.
(Nasdaq: TELK) announced that its novel small molecule proteasome
inhibitor program met a preclinical development milepost by demonstrating
anticancer activity in preclinical models of human leukemia. The proteasome
is an important cellular structure necessary for the growth and function of
cancer cells and suppression of the proteasome has been shown to advertize
cell cycle arrest and cancer cell death or apoptosis. Bortezomib, an
approved drug for the intervention of multiple myeloma, is based on this
mechanism. Telik's proteasome inhibitors are orally active, non-peptide,
non-boron based, and thus whitethorn lead to a drug candidate that might own
advantages over Bortezomib and other proteasome inhibitors.



"The potentially golden profile of these compounds was achieved
through the use of our TRAP(R) computational dose discovery applied science,"
said James Keck, Ph.D., Vice President of Biology at Telik. "We ar
currently conducting activities necessary to blue-ribbon a potency development
candidate."



Preliminary data on Telik's proteasome inhibitor program was presented
at the 2008 annual confluence of the American Association for Cancer Research.



Telik, Inc. of Palo Alto, CA, is a biopharmaceutical company focused on
discovering, developing and commercializing novel small molecule drugs to
treat life-threatening diseases. The company's to the highest degree advanced investigational drug
candidates in clinical development ar TELINTRA(R), a modified glutathione
analog for the treatment of cytopenias due to myelodysplastic syndrome or
chemotherapy, and TELCYTA(R), a tumor-activated prodrug for the discussion
of modern ovarian crab and non-small cell lung cancer. Telik's product
candidates were ascertained using its proprietary drug discovery engineering,
TRAP, which enables the rapid and efficient discovery of pocket-size molecule
dose candidates. Additional information is available at
http://www.telik.com.



This press release contains "forward-looking" statements, including
statements regarding the potential qualities and capabilities of dose
candidates resulting from the small molecule proteasome inhibitor program
described above, including the potency ability of such drug candidates to
prevent or stop neoplasm cell division and starve tumors, and the potentiality
development of any dose candidate to treat genus Cancer. These forward-looking
statements are based upon Telik's flow expectations. There are important
factors that could drive Telik's results to differ materially from those
indicated by these forward-looking statements. Detailed info
regarding factors that crataegus laevigata cause actual results to differ materially from
the results expressed or implied by statements in this press vent may be
found in Telik's periodic filings with the Securities and Exchange
Commission, including the factors described in the surgical incision entitled "Risk
Factors" in its quarterly report on Form 10-Q for the quarter complete June
30, 2008. Telik does not undertake whatsoever obligation to update forward-looking
statements contained in this press release.

TELIK, the Telik logo, TELINTRA, TELCYTA, and TRAP are trademarks or
registered trademarks of Telik, Inc.


Telik, Inc.
http://www.telik.com



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Download June Carter Cash

Artist: June Carter Cash: mp3 download    Genre(s):  Country     Discography:      Keep on the Sunny Side    Year: 2005    Tracks: 38      Church in the Wildwood    Year: 2005    Tracks: 10      Wildwood Flower    Year: 2003    Tracks: 13      Press On    Year: 1999    Tracks: 12 Songwriter, singer, actress, comedienne, and matriarch of country music June Carter Cash was born Valerie June Carter in Maces Springs, VA, on June 23, 1929. Taught by her mother (the legendary Mother Maybelle Carter of the Carter Family) to play autoharp, June entered the limelight in 1937 tattle with her sisters Helen and Anita, finally performing as the Carter Sisters afterwards the death of June's uncle A.P. Her ripe sense of humour and speedy wag prompted June to perform funniness skits and monologues during the show, and light-emitting diode to a bangle recording of "Baby, It's Cold Outside" with country comics Homer & Jethro which finally hit number nine-spot on the country charts in 1949. In 1952, Carter married Carl Smith, with whom she performed at Nashville's Grand Ole Opry, and their daughter, Rebecca Carlene (later to record under the mention Carlene Carter), was born in 1955. After their disjoint in the late '50s, Carter was managed by Colonel Tom Parker and toured with Elvis Presley, and while living in Nashville, she met and briefly marital local constabulary officer Rip Nix with whom she another girl, Rosie. Although Carter dabbled in performing during the '50s, she returned to the musical stage in 1961 when the Carters joined Johnny Cash's road show up. Rumor has it that Cash had unbroken an eye on June since her appearances with the Carter Sisters in the other '50s, commenting, "I'm expiration to marry that girlfriend someday" (contempt the fact that both of them were silent married to other people at the time). In 1963, Carter co-wrote the song "Ring of Fire" with Merle Kilgore, which Cash (purportedly June's inspiration for the song) took to number i. Their Grammy-winning couple "Jackson" came true when Cash and Carter "got married in a fever hotter than a peppercorn sprout" in 1968. Cash has long credited June for forcing him to stir his addiction to amphetamines and encouraging his spiritual development, locution, "she is the person responsible for me silent being alive. She came along at a prison term in my sprightliness when I was going to self-destroy." Another Grammy (for "If I Were a Carpenter") and the parturition of Carter's third child, boy John Carter Cash, followed in 1970. June Carter Cash left the spot for most of the '70s and '80s, stating, "I worked with John, only I had sufficiency sense to walk just a lilliputian shipway behind him. I could have made more than records, only I precious to take a spousal relationship." She did, however, write deuce autobiographies (1979's Among My Klediments and 1987's From My Heart) and likewise did some performing, notably on Dr. Quinn, Medicine Woman and alongside Robert Duvall in The Apostle. She did eventually return to transcription, cathartic a collection of both traditional family line songs and Carter Cash originals entitled Press On in 1999 which won a Grammy for best traditional folk album. Johnny Cash's health seemed to deteriorate end-to-end the '90s just as his career went through a renascence, and many fans were shocked when June Carter Cash died suddenly on May 15, 2003, next complications from spirit surgery. Given the fact that she had remained patently stone solid as he got weaker and weaker, it seemed as though Johnny might go across on, only Carter Cash would live perpetually. Luckily, she does live on today; through the children she raised (many of whom stimulate suit musicians themselves), through her penning and appearances on photographic film, through the contributions she made to her husband's life, and well-nigh intelligibly in the music she left behind.

Beatles - Beatles Tape Sells For 23000

LATEST: A newly-discovered

The Sixth String

   
Artist: The Sixth String

   Genre(s): 
Other
   

---

Discography:


   
 A Typical Dream in Colour

   Year: 2004   
Tracks: 10

---

 

Conrad Schnitzler

   
Artist: Conrad Schnitzler

   Genre(s): 
Electronic
   Classical
   

---

Discography:


   
 Contakt

   Year: 2003   
Tracks: 12


   
 Con '72

   Year: 2001   
Tracks: 2


   
 Acon

   Year: 2000   
Tracks: 17


   
 Convex Live

   Year: 1995   
Tracks: 15


   
 Control Live

   Year: 1995   
Tracks: 25


   
 Blue Glow Live

   Year: 1994   
Tracks: 15


   
 Con Brio

   Year: 1993   
Tracks: 6


   
 Constellations

   Year: 1987   
Tracks: 2


   
 Con 3

   Year: 1982   
Tracks: 9


   
 Rot

   Year: 1981   
Tracks: 2


   
 Auf Dem Schwarzen Kanal

   Year: 1980   
Tracks: 4


   
 Ballet Statique

   Year: 1978   
Tracks: 10


   
 Blau

   Year: 1972   
Tracks: 2


   
 Tracks From The Ivory Tower

   Year:    
Tracks: 5


   
 Electronegativity

   Year:    
Tracks: 8


   
 Convex (Fragments)

   Year:    
Tracks: 3


   
 Consequenz 2

   Year:    
Tracks: 8


   
 Charred Machinery

   Year:    
Tracks: 3


   
 Automat

   Year:    
Tracks: 4


   
 0044

   Year:    
Tracks: 12

---

One of the prime figures in the growth of Kraut-rock, Conrad Schnitzler made authoritative contributions to the former history of Kraftwerk and Kluster. Like many in the Kraut-rock community, Schnitzler was greatly divine by influences in the ocular aesthetic populace as well as the musical; he studied sculpture with Joseph Beuys, and composition with Karlheinz Stockhausen, likewise looking to John Cage and Pierre Schaeffer for intake. By 1969, he was working with Tangerine Dream, with whom he recorded Electronic Meditation. The album became one of the near classifiable in TD's discography, and Schnitzler takes a great deal of the credit for its chance-taking access.


Ahead the end of the decennary, Schnitzler had begun appearing with another soon-to-be Kraut-rock caption, Kluster. Formed with Dieter Moebius and Hans-Joachim Roedelius, the group recorded two albums in 1970, Klopfzeichen and Zwei Osterei. Schnitzler left for a solo calling one year later, though Moebius and Roedelius credibly appeared on his debut, Schwarz (no credits were disposed, merely former musicians toilet be heard). With Schwarz and 1972's Rot, Schnitzler began to progression from by and large acoustic music to a style based around electronics and tape-looped wakeless. Though he continued to record meagerly during the seventies, non much of Schnitzler's work was released until the following decennary. He emerged in 1978 with the album Bunco, recorded at Peter Baumann's Paragon Studios, and with the support of the French mark Egg Records.


The starting time of a new decade resulted in much activity for Conrad Schnitzler, and he released seven albums in add up during 1980-81 alone. The styles ranged from the rough sequencer enchantment of Consequenz to the surprisingly pop-oriented project Hustle 3 (both were recorded with drum machines and vocals by Wolf Sequenza, at one time of Ton Steine Scherben). During the rest of the eighties, Schnitzler recorded oftentimes, only released his act on increasingly obscure labels. After some other fallow stop during the early '90s, he began recording with Plate Lunch Records, which issued new releases such as 1998's 00/44 as well as archival reissues like 1971's Guff.





Simpson's 'eat meat' shirt blasted by Peta

The Fratellis 'Stand' on summer tour dates

Scottish indie rockers The Fratellis [ tickets ] have lined up a short run of US dates to back their sophomore studio effort, "Here We Stand," which is due in stores next week.The Glasgow trio will make the American trip before settling into the summer European festival circuit, kicking off June 11 in Boston. The outing concludes with a June 21 appearance at Calgary, Alberta's Virgin Festival.The group will return to the US in the fall to tackle a slot at Morrison, CO's Monolith Festival. Dates are below."Here We Stand," which drops June 9, is the band's follow-up to its 2006 debut, "Costello Music." The new album was produced by the band in Glasgow and mixed in New York by Andy Wallace (Nirvana, Rage Against the Machine).The set's first single, "Mistress Mabel," was released in late May. The band confirmed on BBC Radio 2 early last month that the second single will be "Lupe Brown," although no release date has been set."Most of the songs seem to be little conversation pieces to me," singer Jon Fratelli said in the band's online bio. "They're almost always a little conversation between two people. That's the pleasure I get from writing them: I don't have to analyze them." The trio--which, a la The Ramones, all go by the surname Fratelli even though only bassist Barry Fratelli has a claim to the name (it's his mother's maiden name)--formed after meeting at a carnival where all the members worked, played their first show in 2005, and were signed by Fallout Records after playing a total of nine gigs.

Radiohead wants Prince cover on YouTube

Thom Yorke questions removal of videos





After word spread that Prince covered Radiohead's "Creep" at the Coachella festival, the tens of thousands who couldn't be there ran to YouTube for a peek. Everyone was quickly denied -- even Radiohead.
All videos of Prince's unique rendition of Radiohead's early hit were quickly taken down, leaving only a message that his label, NPG Records, had removed the clips, claiming a copyright violation. But the posted videos were shot by fans and, obviously, the song isn't Prince's.
In a recent interview, Thom Yorke said he heard about Prince's performance from a text message and thought it was "hilarious." Yorke laughed when his bandmate, guitarist Ed O'Brien, said the blocking had prevented even him from seeing Prince's version of their song.
"Really? He's blocked it?" asked Yorke, who figured it was their song to block or not. "Surely we should block it. Hang on a moment." Yorke added, "Well, tell him to unblock it. It's our ... song."
YouTube prohibits the posting of copyrighted material. If the site receives a complaint from a copyright owner, it will in most cases remove the video(s). Whether the same could be done for a company not holding a copyright is less clear, but Yorke's argument would seem to bear some credence according to YouTube's policies. YouTube, which is owned by Google, declined comment.
Prince has not responded to a request for comment.
The dispute was an interesting twist in debates over digital ownership, held between two major acts with differing views on music and the Internet. Radiohead famously released their most recent album, "In Rainbows," as a digital download with optional pricing. They also have a channel on YouTube.
When Prince performed at Coachella on April 26, he prohibited the standard arrangement of allowing photographers to shoot near the stage during the first three songs of his set. Instead, he had a camera crew filming his performance.
Prince, who founded NPG Records in 1993, has been innovative when it comes to music distribution, too. He released his 1997 album, "Crystal Ball," on the Internet and in 2006 was awarded a lifetime achievement award by the Webbys. In 2007, he gave away copies of his disc "Planet Earth" in a British Sunday newspaper.
But Prince has also shut down his official Web site and in September said he would sue YouTube and eBay for not filtering unauthorized content.
Prince fans have organized to urge him to relent in his legal fights to control images and photographs of himself. As of yesterday, the most popular YouTube clip about Prince playing "Creep" is an expletive-laden rant from Sam Conti Jr., who describes himself as a "former Prince fan."